000 01939 a2200553 4500
005 20250515135633.0
264 0 _c20090424
008 200904s 0 0 eng d
022 _a1464-3405
024 7 _a10.1016/j.bmcl.2008.08.112
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPingali, Harikishore
245 0 0 _aDiscovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_cOct 2008
300 _a5586-90 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aCarboxylic Acids
_xchemical synthesis
650 0 4 _aDiabetes Mellitus, Type 2
_xdrug therapy
650 0 4 _aDioxanes
_xchemical synthesis
650 0 4 _aHumans
650 0 4 _aHypoglycemic Agents
_xchemical synthesis
650 0 4 _aHypolipidemic Agents
_xchemical synthesis
650 0 4 _aLipids
_xchemistry
650 0 4 _aMesylates
_xchemical synthesis
650 0 4 _aMice
650 0 4 _aModels, Chemical
650 0 4 _aPPAR alpha
_xmetabolism
650 0 4 _aPPAR gamma
_xmetabolism
650 0 4 _aPeroxisome Proliferator-Activated Receptors
_xagonists
650 0 4 _aRats
650 0 4 _aRats, Wistar
650 0 4 _aTranscriptional Activation
700 1 _aJain, Mukul
700 1 _aShah, Shailesh
700 1 _aBasu, Sujay
700 1 _aMakadia, Pankaj
700 1 _aGoswami, Amitgiri
700 1 _aZaware, Pandurang
700 1 _aPatil, Pravin
700 1 _aGodha, Atul
700 1 _aGiri, Suresh
700 1 _aGoel, Ashish
700 1 _aPatel, Megha
700 1 _aPatel, Harilal
700 1 _aPatel, Pankaj
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 18
_gno. 20
_gp. 5586-90
856 4 0 _uhttps://doi.org/10.1016/j.bmcl.2008.08.112
_zAvailable from publisher's website
999 _c18272727
_d18272727