000			02271 a2200673 4500
005			20250515134909.0
264		0	_c20081030
008			200810s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm800214a _2doi
040			_aNLM _beng _cNLM
100	1		_aCole, Derek C
245	0	0	_aIdentification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. _h[electronic resource]
260			_bJournal of medicinal chemistry _cOct 2008
300			_a5958-63 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAnimals
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDrug Evaluation, Preclinical
650	0	4	_aFemale
650	0	4	_aIndoles _xchemical synthesis
650	0	4	_aInterleukin-2 _xantagonists & inhibitors
650	0	4	_aIsoenzymes _xantagonists & inhibitors
650	0	4	_aMice
650	0	4	_aMice, Inbred C57BL
650	0	4	_aMice, Knockout
650	0	4	_aModels, Molecular
650	0	4	_aMolecular Structure
650	0	4	_aNitriles _xchemical synthesis
650	0	4	_aProtein Kinase C _xantagonists & inhibitors
650	0	4	_aProtein Kinase C-theta
650	0	4	_aProtein Kinase Inhibitors _xchemical synthesis
650	0	4	_aPyridines _xchemical synthesis
650	0	4	_aSpleen _xcytology
650	0	4	_aStereoisomerism
650	0	4	_aStructure-Activity Relationship
650	0	4	_aT-Lymphocytes _xdrug effects
700	1		_aAsselin, Magda
700	1		_aBrennan, Agnes
700	1		_aCzerwinski, Robert
700	1		_aEllingboe, John W
700	1		_aFitz, Lori
700	1		_aGreco, Rita
700	1		_aHuang, Xinyi
700	1		_aJoseph-McCarthy, Diane
700	1		_aKelly, Michael F
700	1		_aKirisits, Matthew
700	1		_aLee, Julie
700	1		_aLi, Yuanhong
700	1		_aMorgan, Paul
700	1		_aStock, Joseph R
700	1		_aTsao, Désirée H H
700	1		_aWissner, Allan
700	1		_aYang, Xiaoke
700	1		_aChaudhary, Divya
773	0		_tJournal of medicinal chemistry _gvol. 51 _gno. 19 _gp. 5958-63
856	4	0	_uhttps://doi.org/10.1021/jm800214a _zAvailable from publisher's website
999			_c18252208 _d18252208