000 01752 a2200469 4500
005 20250515134412.0
264 0 _c20080930
008 200809s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.0800041105
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aFujishita, Teruaki
245 0 0 _aInhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_cSep 2008
300 _a13544-9 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdenoma
_xblood supply
650 0 4 _aAdenomatous Polyposis Coli Protein
_xgenetics
650 0 4 _aAnimals
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aEverolimus
650 0 4 _aFemale
650 0 4 _aIntestinal Polyps
_xmetabolism
650 0 4 _aMale
650 0 4 _aMechanistic Target of Rapamycin Complex 1
650 0 4 _aMice
650 0 4 _aMice, Transgenic
650 0 4 _aMultiprotein Complexes
650 0 4 _aProteins
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSirolimus
_xanalogs & derivatives
650 0 4 _aSurvival Rate
650 0 4 _aTOR Serine-Threonine Kinases
650 0 4 _aTranscription Factors
_xmetabolism
650 0 4 _aWnt Proteins
_xmetabolism
700 1 _aAoki, Koji
700 1 _aLane, Heidi A
700 1 _aAoki, Masahiro
700 1 _aTaketo, Makoto M
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 105
_gno. 36
_gp. 13544-9
856 4 0 _uhttps://doi.org/10.1073/pnas.0800041105
_zAvailable from publisher's website
999 _c18238772
_d18238772