000 01961 a2200517 4500
005 20250515134054.0
264 0 _c20080930
008 200809s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.0806268105
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aShibata, Tatsuhiro
245 0 0 _aCancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_cSep 2008
300 _a13568-73 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aActive Transport, Cell Nucleus
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aBase Sequence
650 0 4 _aCell Line, Tumor
650 0 4 _aCullin Proteins
_xmetabolism
650 0 4 _aDown-Regulation
_xdrug effects
650 0 4 _aGene Expression Regulation, Neoplastic
_xdrug effects
650 0 4 _aHumans
650 0 4 _aIntracellular Signaling Peptides and Proteins
_xmetabolism
650 0 4 _aKelch-Like ECH-Associated Protein 1
650 0 4 _aModels, Molecular
650 0 4 _aMutation
_xgenetics
650 0 4 _aNF-E2-Related Factor 2
_xchemistry
650 0 4 _aNeoplasms
_xgenetics
650 0 4 _aOxidative Stress
650 0 4 _aProtein Binding
650 0 4 _aProtein Structure, Tertiary
650 0 4 _aSubstrate Specificity
650 0 4 _aTranscription, Genetic
_xgenetics
700 1 _aOhta, Tsutomu
700 1 _aTong, Kit I
700 1 _aKokubu, Akiko
700 1 _aOdogawa, Reiko
700 1 _aTsuta, Koji
700 1 _aAsamura, Hisao
700 1 _aYamamoto, Masayuki
700 1 _aHirohashi, Setsuo
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 105
_gno. 36
_gp. 13568-73
856 4 0 _uhttps://doi.org/10.1073/pnas.0806268105
_zAvailable from publisher's website
999 _c18228247
_d18228247