| 000 | 01847 a2200517 4500 | ||
|---|---|---|---|
| 005 | 20250515125804.0 | ||
| 264 | 0 | _c20080925 | |
| 008 | 200809s 0 0 eng d | ||
| 022 | _a1524-4628 | ||
| 024 | 7 |
_a10.1161/STROKEAHA.107.510164 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aWhelan, Harry T | |
| 245 | 0 | 0 |
_aPractical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children. _h[electronic resource] |
| 260 |
_bStroke _cSep 2008 |
||
| 300 |
_a2627-36 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAdolescent |
| 650 | 0 | 4 | _aAge Factors |
| 650 | 0 | 4 | _aBayes Theorem |
| 650 | 0 | 4 |
_aBrain Ischemia _xdrug therapy |
| 650 | 0 | 4 | _aChild |
| 650 | 0 | 4 | _aChild, Preschool |
| 650 | 0 | 4 | _aClinical Protocols |
| 650 | 0 | 4 |
_aClinical Trials as Topic _xmethods |
| 650 | 0 | 4 | _aCohort Studies |
| 650 | 0 | 4 | _aComputer Simulation |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aDrug-Related Side Effects and Adverse Reactions |
| 650 | 0 | 4 |
_aFibrinolytic Agents _xadministration & dosage |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aInfant |
| 650 | 0 | 4 | _aModels, Statistical |
| 650 | 0 | 4 | _aResearch Design |
| 650 | 0 | 4 |
_aStroke _xdrug therapy |
| 650 | 0 | 4 |
_aTissue Plasminogen Activator _xadministration & dosage |
| 650 | 0 | 4 | _aTreatment Outcome |
| 700 | 1 | _aCook, John D | |
| 700 | 1 | _aAmlie-Lefond, Catherine M | |
| 700 | 1 | _aHovinga, Collin A | |
| 700 | 1 | _aChan, Anthony K | |
| 700 | 1 | _aIchord, Rebecca N | |
| 700 | 1 | _aDeveber, Gabrielle A | |
| 700 | 1 | _aThall, Peter F | |
| 773 | 0 |
_tStroke _gvol. 39 _gno. 9 _gp. 2627-36 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1161/STROKEAHA.107.510164 _zAvailable from publisher's website |
| 999 |
_c18099047 _d18099047 |
||