000 02117 a2200577 4500
005 20250515124718.0
264 0 _c20081126
008 200811s 0 0 eng d
022 _a0731-7085
024 7 _a10.1016/j.jpba.2008.05.011
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aYoudim, Kuresh A
245 0 0 _aAn automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
_h[electronic resource]
260 _bJournal of pharmaceutical and biomedical analysis
_cSep 2008
300 _a92-9 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAryl Hydrocarbon Hydroxylases
_xanalysis
650 0 4 _aBiological Assay
650 0 4 _aChromatography, Liquid
_xmethods
650 0 4 _aCytochrome P-450 CYP1A2
_xanalysis
650 0 4 _aCytochrome P-450 CYP2B6
650 0 4 _aCytochrome P-450 CYP2C19
650 0 4 _aCytochrome P-450 CYP2C9
650 0 4 _aCytochrome P-450 CYP2D6
_xanalysis
650 0 4 _aCytochrome P-450 CYP3A
_xanalysis
650 0 4 _aCytochrome P-450 Enzyme System
_xanalysis
650 0 4 _aDextromethorphan
_xmetabolism
650 0 4 _aDiclofenac
_xmetabolism
650 0 4 _aDrug Interactions
650 0 4 _aHumans
650 0 4 _aHydrogen-Ion Concentration
650 0 4 _aInhibitory Concentration 50
650 0 4 _aKinetics
650 0 4 _aMicrosomes, Liver
_xchemistry
650 0 4 _aMidazolam
_xmetabolism
650 0 4 _aMiniaturization
650 0 4 _aOxidoreductases, N-Demethylating
_xmetabolism
650 0 4 _aReference Standards
650 0 4 _aReproducibility of Results
650 0 4 _aSensitivity and Specificity
650 0 4 _aSubstrate Specificity
_xdrug effects
650 0 4 _aTacrine
_xmetabolism
650 0 4 _aTandem Mass Spectrometry
_xmethods
650 0 4 _aTime Factors
700 1 _aLyons, Richard
700 1 _aPayne, Leon
700 1 _aJones, Barry C
700 1 _aSaunders, Kenneth
773 0 _tJournal of pharmaceutical and biomedical analysis
_gvol. 48
_gno. 1
_gp. 92-9
856 4 0 _uhttps://doi.org/10.1016/j.jpba.2008.05.011
_zAvailable from publisher's website
999 _c18068327
_d18068327