| 000 | 02175 a2200613 4500 | ||
|---|---|---|---|
| 005 | 20250515124510.0 | ||
| 264 | 0 | _c20080829 | |
| 008 | 200808s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm800386y _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aCox, Christopher D | |
| 245 | 0 | 0 |
_aKinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cJul 2008 |
||
| 300 |
_a4239-52 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 |
_aATP Binding Cassette Transporter, Subfamily B, Member 1 _xmetabolism |
| 650 | 0 | 4 |
_aAntineoplastic Agents _xpharmacology |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xpharmacology |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aKinesins _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aNeoplasms _xdrug therapy |
| 650 | 0 | 4 |
_aPiperidines _xpharmacology |
| 650 | 0 | 4 |
_aPyrroles _xpharmacology |
| 650 | 0 | 4 |
_aTaxoids _xpharmacology |
| 700 | 1 | _aColeman, Paul J | |
| 700 | 1 | _aBreslin, Michael J | |
| 700 | 1 | _aWhitman, David B | |
| 700 | 1 | _aGarbaccio, Robert M | |
| 700 | 1 | _aFraley, Mark E | |
| 700 | 1 | _aBuser, Carolyn A | |
| 700 | 1 | _aWalsh, Eileen S | |
| 700 | 1 | _aHamilton, Kelly | |
| 700 | 1 | _aSchaber, Michael D | |
| 700 | 1 | _aLobell, Robert B | |
| 700 | 1 | _aTao, Weikang | |
| 700 | 1 | _aDavide, Joseph P | |
| 700 | 1 | _aDiehl, Ronald E | |
| 700 | 1 | _aAbrams, Marc T | |
| 700 | 1 | _aSouth, Vicki J | |
| 700 | 1 | _aHuber, Hans E | |
| 700 | 1 | _aTorrent, Maricel | |
| 700 | 1 | _aPrueksaritanont, Thomayant | |
| 700 | 1 | _aLi, Chunze | |
| 700 | 1 | _aSlaughter, Donald E | |
| 700 | 1 | _aMahan, Elizabeth | |
| 700 | 1 | _aFernandez-Metzler, Carmen | |
| 700 | 1 | _aYan, Youwei | |
| 700 | 1 | _aKuo, Lawrence C | |
| 700 | 1 | _aKohl, Nancy E | |
| 700 | 1 | _aHartman, George D | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 51 _gno. 14 _gp. 4239-52 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm800386y _zAvailable from publisher's website |
| 999 |
_c18062215 _d18062215 |
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