000 02036 a2200601 4500
005 20250515112530.0
264 0 _c20080807
008 200808s 0 0 eng d
022 _a1476-5594
024 7 _a10.1038/onc.2008.49
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSteelman, L S
245 0 0 _aSuppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
_h[electronic resource]
260 _bOncogene
_cJul 2008
300 _a4086-95 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAmino Acid Substitution
650 0 4 _aAntibiotics, Antineoplastic
_xagonists
650 0 4 _aBreast Neoplasms
_xdrug therapy
650 0 4 _aCell Line, Tumor
650 0 4 _aDoxorubicin
_xagonists
650 0 4 _aDrug Resistance, Neoplasm
_xdrug effects
650 0 4 _aDrug Synergism
650 0 4 _aFemale
650 0 4 _aGene Expression
650 0 4 _aHumans
650 0 4 _aMutation, Missense
650 0 4 _aPTEN Phosphohydrolase
_xantagonists & inhibitors
650 0 4 _aProtein Kinases
_xgenetics
650 0 4 _aProto-Oncogene Proteins c-akt
_xgenetics
650 0 4 _aRibosomal Protein S6 Kinases, 70-kDa
_xgenetics
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSirolimus
_xagonists
650 0 4 _aTOR Serine-Threonine Kinases
650 0 4 _aTransfection
700 1 _aNavolanic, P M
700 1 _aSokolosky, M L
700 1 _aTaylor, J R
700 1 _aLehmann, B D
700 1 _aChappell, W H
700 1 _aAbrams, S L
700 1 _aWong, E W T
700 1 _aStadelman, K M
700 1 _aTerrian, D M
700 1 _aLeslie, N R
700 1 _aMartelli, A M
700 1 _aStivala, F
700 1 _aLibra, M
700 1 _aFranklin, R A
700 1 _aMcCubrey, J A
773 0 _tOncogene
_gvol. 27
_gno. 29
_gp. 4086-95
856 4 0 _uhttps://doi.org/10.1038/onc.2008.49
_zAvailable from publisher's website
999 _c17834887
_d17834887