000 01877 a2200505 4500
005 20250515110646.0
264 0 _c20080505
008 200805s 0 0 eng d
022 _a1524-4571
024 7 _a10.1161/CIRCRESAHA.107.161679
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aVinogradova, Tatiana M
245 0 0 _aConstitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.
_h[electronic resource]
260 _bCirculation research
_cApr 2008
300 _a761-9 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Intramural
650 0 4 _a1-Methyl-3-isobutylxanthine
_xpharmacology
650 0 4 _aAnimals
650 0 4 _aBiological Clocks
_xphysiology
650 0 4 _aCalcium
_xmetabolism
650 0 4 _aCalcium-Binding Proteins
_xmetabolism
650 0 4 _aCyclic AMP
_xmetabolism
650 0 4 _aCyclic AMP-Dependent Protein Kinases
_xmetabolism
650 0 4 _aEnzyme Activation
650 0 4 _aHeart Rate
_xphysiology
650 0 4 _aPatch-Clamp Techniques
650 0 4 _aPhosphodiesterase Inhibitors
_xpharmacology
650 0 4 _aPhosphoric Diester Hydrolases
_xdrug effects
650 0 4 _aPhosphorylation
650 0 4 _aRabbits
650 0 4 _aRyanodine Receptor Calcium Release Channel
_xmetabolism
650 0 4 _aSignal Transduction
_xphysiology
650 0 4 _aSinoatrial Node
_xmetabolism
700 1 _aSirenko, Syevda
700 1 _aLyashkov, Alexey E
700 1 _aYounes, Antoine
700 1 _aLi, Yue
700 1 _aZhu, Weizhong
700 1 _aYang, Dongmei
700 1 _aRuknudin, Abdul M
700 1 _aSpurgeon, Harold
700 1 _aLakatta, Edward G
773 0 _tCirculation research
_gvol. 102
_gno. 7
_gp. 761-9
856 4 0 _uhttps://doi.org/10.1161/CIRCRESAHA.107.161679
_zAvailable from publisher's website
999 _c17781625
_d17781625