000 01659 a2200421 4500
005 20250515103705.0
264 0 _c20080512
008 200805s 0 0 eng d
022 _a0021-9258
024 7 _a10.1074/jbc.M708362200
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHook, Vivian Y H
245 0 0 _aInhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
_h[electronic resource]
260 _bThe Journal of biological chemistry
_cMar 2008
300 _a7745-53 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural
650 0 4 _aAlzheimer Disease
_xdrug therapy
650 0 4 _aAmyloid Precursor Protein Secretases
_xantagonists & inhibitors
650 0 4 _aAmyloid beta-Protein Precursor
_xgenetics
650 0 4 _aAnimals
650 0 4 _aCathepsin B
_xgenetics
650 0 4 _aCattle
650 0 4 _aCysteine Proteinase Inhibitors
_xpharmacology
650 0 4 _aDipeptides
_xpharmacology
650 0 4 _aDisease Models, Animal
650 0 4 _aDrug Evaluation, Preclinical
650 0 4 _aGene Expression
650 0 4 _aHumans
650 0 4 _aLeucine
_xanalogs & derivatives
650 0 4 _aMaze Learning
_xdrug effects
650 0 4 _aMemory
_xdrug effects
650 0 4 _aMice
650 0 4 _aMice, Transgenic
700 1 _aKindy, Mark
700 1 _aHook, Gregory
773 0 _tThe Journal of biological chemistry
_gvol. 283
_gno. 12
_gp. 7745-53
856 4 0 _uhttps://doi.org/10.1074/jbc.M708362200
_zAvailable from publisher's website
999 _c17694418
_d17694418