000 02432 a2200805 4500
005 20250515095235.0
264 0 _c20080107
008 200801s 0 0 eng d
022 _a1476-4687
024 7 _a10.1038/nature06261
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMilne, Jill C
245 0 0 _aSmall molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
_h[electronic resource]
260 _bNature
_cNov 2007
300 _a712-6 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAcetylation
650 0 4 _aAllosteric Site
650 0 4 _aAnimals
650 0 4 _aBlood Glucose
_xmetabolism
650 0 4 _aCaloric Restriction
650 0 4 _aCatalytic Domain
650 0 4 _aCell Line
650 0 4 _aDiabetes Mellitus, Type 2
_xdrug therapy
650 0 4 _aDietary Fats
_xadministration & dosage
650 0 4 _aDisease Models, Animal
650 0 4 _aDrosophila melanogaster
650 0 4 _aHeterocyclic Compounds, 4 or More Rings
_xpharmacology
650 0 4 _aHumans
650 0 4 _aInsulin
_xmetabolism
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMitochondria
_xdrug effects
650 0 4 _aRats
650 0 4 _aRats, Sprague-Dawley
650 0 4 _aRats, Zucker
650 0 4 _aResveratrol
650 0 4 _aSirtuin 1
650 0 4 _aSirtuins
_xagonists
650 0 4 _aStilbenes
_xchemistry
700 1 _aLambert, Philip D
700 1 _aSchenk, Simon
700 1 _aCarney, David P
700 1 _aSmith, Jesse J
700 1 _aGagne, David J
700 1 _aJin, Lei
700 1 _aBoss, Olivier
700 1 _aPerni, Robert B
700 1 _aVu, Chi B
700 1 _aBemis, Jean E
700 1 _aXie, Roger
700 1 _aDisch, Jeremy S
700 1 _aNg, Pui Yee
700 1 _aNunes, Joseph J
700 1 _aLynch, Amy V
700 1 _aYang, Hongying
700 1 _aGalonek, Heidi
700 1 _aIsraelian, Kristine
700 1 _aChoy, Wendy
700 1 _aIffland, Andre
700 1 _aLavu, Siva
700 1 _aMedvedik, Oliver
700 1 _aSinclair, David A
700 1 _aOlefsky, Jerrold M
700 1 _aJirousek, Michael R
700 1 _aElliott, Peter J
700 1 _aWestphal, Christoph H
773 0 _tNature
_gvol. 450
_gno. 7170
_gp. 712-6
856 4 0 _uhttps://doi.org/10.1038/nature06261
_zAvailable from publisher's website
999 _c17561241
_d17561241