| 000 | 01550 a2200433 4500 | ||
|---|---|---|---|
| 005 | 20250515091634.0 | ||
| 264 | 0 | _c20080303 | |
| 008 | 200803s 0 0 eng d | ||
| 022 | _a1464-3405 | ||
| 024 | 7 |
_a10.1016/j.bmcl.2007.09.063 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aTao, Zhi-Fu | |
| 245 | 0 | 0 |
_aMacrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. _h[electronic resource] |
| 260 |
_bBioorganic & medicinal chemistry letters _cDec 2007 |
||
| 300 |
_a6593-601 p. _bdigital |
||
| 500 | _aPublication Type: Comparative Study; Journal Article | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aCatalysis |
| 650 | 0 | 4 | _aCheckpoint Kinase 1 |
| 650 | 0 | 4 | _aHeLa Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aMacrocyclic Compounds _xchemical synthesis |
| 650 | 0 | 4 | _aMice |
| 650 | 0 | 4 |
_aProtein Kinase Inhibitors _xchemical synthesis |
| 650 | 0 | 4 |
_aProtein Kinases _xpharmacokinetics |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aUrea _xchemical synthesis |
| 700 | 1 | _aChen, Zehan | |
| 700 | 1 | _aBui, Mai-Ha | |
| 700 | 1 | _aKovar, Peter | |
| 700 | 1 | _aJohnson, Eric | |
| 700 | 1 | _aBouska, Jennifer | |
| 700 | 1 | _aZhang, Haiying | |
| 700 | 1 | _aRosenberg, Saul | |
| 700 | 1 | _aSowin, Thomas | |
| 700 | 1 | _aLin, Nan-Horng | |
| 773 | 0 |
_tBioorganic & medicinal chemistry letters _gvol. 17 _gno. 23 _gp. 6593-601 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1016/j.bmcl.2007.09.063 _zAvailable from publisher's website |
| 999 |
_c17456531 _d17456531 |
||