000 02111 a2200577 4500
005 20250515084318.0
264 0 _c20080103
008 200801s 0 0 eng d
022 _a0090-9556
024 7 _a10.1124/dmd.107.017517
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGhosal, Anima
245 0 0 _aIdentification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.
_h[electronic resource]
260 _bDrug metabolism and disposition: the biological fate of chemicals
_cDec 2007
300 _a2186-95 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAntibodies, Monoclonal
650 0 4 _aAryl Hydrocarbon Hydroxylases
_xmetabolism
650 0 4 _aBiotransformation
650 0 4 _aBridged-Ring Compounds
_xpharmacology
650 0 4 _aCCR5 Receptor Antagonists
650 0 4 _aCarboxylic Acids
_xmetabolism
650 0 4 _aCytochrome P-450 CYP2C9
650 0 4 _aCytochrome P-450 CYP3A
650 0 4 _aCytochrome P-450 Enzyme Inhibitors
650 0 4 _aCytochrome P-450 Enzyme System
_ximmunology
650 0 4 _aDealkylation
650 0 4 _aEnzyme Inhibitors
_xpharmacology
650 0 4 _aHumans
650 0 4 _aImmunologic Factors
_xmetabolism
650 0 4 _aIn Vitro Techniques
650 0 4 _aIsoenzymes
_xmetabolism
650 0 4 _aKetoconazole
_xpharmacology
650 0 4 _aKinetics
650 0 4 _aLiver
_xdrug effects
650 0 4 _aOxidation-Reduction
650 0 4 _aPiperazines
_xmetabolism
650 0 4 _aPyrimidines
_xmetabolism
650 0 4 _aRecombinant Proteins
_xmetabolism
650 0 4 _aSubstrate Specificity
650 0 4 _aTestosterone
_xmetabolism
650 0 4 _aTriazoles
_xpharmacology
700 1 _aRamanathan, Ragu
700 1 _aYuan, Yuan
700 1 _aHapangama, Neil
700 1 _aChowdhury, Swapan K
700 1 _aKishnani, Narendra S
700 1 _aAlton, Kevin B
773 0 _tDrug metabolism and disposition: the biological fate of chemicals
_gvol. 35
_gno. 12
_gp. 2186-95
856 4 0 _uhttps://doi.org/10.1124/dmd.107.017517
_zAvailable from publisher's website
999 _c17355507
_d17355507