| 000 | 02002 a2200517 4500 | ||
|---|---|---|---|
| 005 | 20250515075349.0 | ||
| 264 | 0 | _c20071107 | |
| 008 | 200711s 0 0 eng d | ||
| 022 | _a0021-9258 | ||
| 024 | 7 |
_a10.1074/jbc.M703461200 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aPlaza-Menacho, Iván | |
| 245 | 0 | 0 |
_aSorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. _h[electronic resource] |
| 260 |
_bThe Journal of biological chemistry _cOct 2007 |
||
| 300 |
_a29230-40 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 |
_aBenzenesulfonates _xpharmacology |
| 650 | 0 | 4 | _aCell Line |
| 650 | 0 | 4 | _aCell Line, Tumor |
| 650 | 0 | 4 | _aCell Proliferation |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aInhibitory Concentration 50 |
| 650 | 0 | 4 |
_aLysosomes _xmetabolism |
| 650 | 0 | 4 |
_aMitogen-Activated Protein Kinase 1 _xmetabolism |
| 650 | 0 | 4 |
_aMitogen-Activated Protein Kinase 3 _xmetabolism |
| 650 | 0 | 4 |
_aMultiple Endocrine Neoplasia Type 2a _xmetabolism |
| 650 | 0 | 4 |
_aNiacinamide _xanalogs & derivatives |
| 650 | 0 | 4 | _aPhenylurea Compounds |
| 650 | 0 | 4 | _aPhosphorylation |
| 650 | 0 | 4 |
_aProteasome Endopeptidase Complex _xmetabolism |
| 650 | 0 | 4 |
_aProtein Kinase Inhibitors _xpharmacology |
| 650 | 0 | 4 |
_aProto-Oncogene Proteins B-raf _xmetabolism |
| 650 | 0 | 4 |
_aProto-Oncogene Proteins c-ret _xmetabolism |
| 650 | 0 | 4 |
_aPyridines _xpharmacology |
| 650 | 0 | 4 | _aSorafenib |
| 700 | 1 | _aMologni, Luca | |
| 700 | 1 | _aSala, Elisa | |
| 700 | 1 | _aGambacorti-Passerini, Carlo | |
| 700 | 1 | _aMagee, Anthony I | |
| 700 | 1 | _aLinks, Thera P | |
| 700 | 1 | _aHofstra, Robert M W | |
| 700 | 1 | _aBarford, David | |
| 700 | 1 | _aIsacke, Clare M | |
| 773 | 0 |
_tThe Journal of biological chemistry _gvol. 282 _gno. 40 _gp. 29230-40 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1074/jbc.M703461200 _zAvailable from publisher's website |
| 999 |
_c17197399 _d17197399 |
||