000			02084 a2200577 4500
005			20250515061541.0
264		0	_c20070911
008			200709s 0 0 eng d
022			_a0009-9236
024	7		_a10.1038/sj.clpt.6100122 _2doi
040			_aNLM _beng _cNLM
100	1		_aParikh, S
245	0	0	_aAmodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. _h[electronic resource]
260			_bClinical pharmacology and therapeutics _cAug 2007
300			_a197-203 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
650	0	4	_aAlkynes
650	0	4	_aAmodiaquine _xanalogs & derivatives
650	0	4	_aAntimalarials _xmetabolism
650	0	4	_aAryl Hydrocarbon Hydroxylases _xgenetics
650	0	4	_aBenzoxazines _xmetabolism
650	0	4	_aBurkina Faso
650	0	4	_aChromatography, High Pressure Liquid
650	0	4	_aCyclopropanes
650	0	4	_aCytochrome P-450 CYP2C8
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aDrug Interactions
650	0	4	_aEnzyme Inhibitors _xmetabolism
650	0	4	_aGenotype
650	0	4	_aHIV Protease Inhibitors _xmetabolism
650	0	4	_aHumans
650	0	4	_aLopinavir
650	0	4	_aMalaria, Falciparum _xdrug therapy
650	0	4	_aModels, Biological
650	0	4	_aPolymorphism, Genetic
650	0	4	_aPyridines _xmetabolism
650	0	4	_aPyrimidinones _xmetabolism
650	0	4	_aPyrones _xmetabolism
650	0	4	_aReverse Transcriptase Inhibitors _xmetabolism
650	0	4	_aSaquinavir _xmetabolism
650	0	4	_aSpectrophotometry, Ultraviolet
650	0	4	_aSulfonamides
650	0	4	_aTreatment Outcome
650	0	4	_aTrimethoprim _xmetabolism
700	1		_aOuedraogo, J-B
700	1		_aGoldstein, J A
700	1		_aRosenthal, P J
700	1		_aKroetz, D L
773	0		_tClinical pharmacology and therapeutics _gvol. 82 _gno. 2 _gp. 197-203
856	4	0	_uhttps://doi.org/10.1038/sj.clpt.6100122 _zAvailable from publisher's website
999			_c16916697 _d16916697