000 02208 a2200601 4500
005 20250515060932.0
264 0 _c20070524
008 200705s 0 0 eng d
022 _a0007-1188
024 7 _a10.1038/sj.bjp.0707189
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHinke, S A
245 0 0 _aMethyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
_h[electronic resource]
260 _bBritish journal of pharmacology
_cApr 2007
300 _a1031-43 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAMP-Activated Protein Kinases
650 0 4 _aAnimals
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aBiguanides
_xantagonists & inhibitors
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aElectron Transport
_xdrug effects
650 0 4 _aElectron Transport Complex I
_xantagonists & inhibitors
650 0 4 _aElectron Transport Complex II
_xdrug effects
650 0 4 _aEnzyme Activation
_xdrug effects
650 0 4 _aGlucose
_xmetabolism
650 0 4 _aHypoglycemic Agents
_xantagonists & inhibitors
650 0 4 _aInsulin-Secreting Cells
_xdrug effects
650 0 4 _aMetformin
_xtoxicity
650 0 4 _aMice
650 0 4 _aMitochondria
_xdrug effects
650 0 4 _aMultienzyme Complexes
_xmetabolism
650 0 4 _aNADP
_xmetabolism
650 0 4 _aOxidation-Reduction
650 0 4 _aPhenformin
_xtoxicity
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aProtein Serine-Threonine Kinases
_xmetabolism
650 0 4 _aRats
650 0 4 _aSuccinates
_xmetabolism
650 0 4 _aTetrazolium Salts
_xmetabolism
650 0 4 _aThiazoles
_xmetabolism
650 0 4 _aTime Factors
700 1 _aMartens, G A
700 1 _aCai, Y
700 1 _aFinsi, J
700 1 _aHeimberg, H
700 1 _aPipeleers, D
700 1 _aVan de Casteele, M
773 0 _tBritish journal of pharmacology
_gvol. 150
_gno. 8
_gp. 1031-43
856 4 0 _uhttps://doi.org/10.1038/sj.bjp.0707189
_zAvailable from publisher's website
999 _c16896807
_d16896807