000 01769 a2200481 4500
005 20250515034824.0
264 0 _c20060913
008 200609s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm0512591
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPalmer, Brian D
245 0 0 _a4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cAug 2006
300 _a4896-911 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aBenzene Derivatives
_xchemical synthesis
650 0 4 _aCarbazoles
_xchemical synthesis
650 0 4 _aCell Cycle Proteins
_xantagonists & inhibitors
650 0 4 _aCheckpoint Kinase 1
650 0 4 _aCrystallography, X-Ray
650 0 4 _aHumans
650 0 4 _aModels, Molecular
650 0 4 _aNuclear Proteins
_xantagonists & inhibitors
650 0 4 _aProtein Binding
650 0 4 _aProtein Kinases
_xchemistry
650 0 4 _aProtein-Tyrosine Kinases
_xantagonists & inhibitors
650 0 4 _aPyrroles
_xchemical synthesis
650 0 4 _aStructure-Activity Relationship
700 1 _aThompson, Andrew M
700 1 _aBooth, R John
700 1 _aDobrusin, Ellen M
700 1 _aKraker, Alan J
700 1 _aLee, Ho H
700 1 _aLunney, Elizabeth A
700 1 _aMitchell, Lorna H
700 1 _aOrtwine, Daniel F
700 1 _aSmaill, Jeff B
700 1 _aSwan, Leesa M
700 1 _aDenny, William A
773 0 _tJournal of medicinal chemistry
_gvol. 49
_gno. 16
_gp. 4896-911
856 4 0 _uhttps://doi.org/10.1021/jm0512591
_zAvailable from publisher's website
999 _c16472874
_d16472874