000 02951 a2200829 4500
005 20250515033301.0
264 0 _c20070212
008 200702s 0 0 eng d
022 _a1549-1676
024 7 _a10.1371/journal.pmed.0030270
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPikman, Yana
245 0 0 _aMPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.
_h[electronic resource]
260 _bPLoS medicine
_cJul 2006
300 _ae270 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAmino Acid Substitution
650 0 4 _aAnimals
650 0 4 _aBone Marrow Cells
_xdrug effects
650 0 4 _aBone Marrow Transplantation
650 0 4 _aCell Division
_xdrug effects
650 0 4 _aCells, Cultured
_xdrug effects
650 0 4 _aColony-Forming Units Assay
650 0 4 _aCytokines
_xpharmacology
650 0 4 _aDisease Models, Animal
650 0 4 _aGene Expression Regulation
650 0 4 _aGenetic Vectors
650 0 4 _aHematologic Neoplasms
_xdrug therapy
650 0 4 _aHematopoiesis
_xgenetics
650 0 4 _aHumans
650 0 4 _aJanus Kinases
_xantagonists & inhibitors
650 0 4 _aMegakaryocytes
_xdrug effects
650 0 4 _aMice
650 0 4 _aMice, Inbred BALB C
650 0 4 _aMutation, Missense
650 0 4 _aMyeloid Cells
_xdrug effects
650 0 4 _aMyeloproliferative Disorders
_xetiology
650 0 4 _aOncogene Proteins, Fusion
_xgenetics
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aPoint Mutation
650 0 4 _aPrimary Myelofibrosis
_xgenetics
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aProtein Processing, Post-Translational
_xdrug effects
650 0 4 _aReceptor, Platelet-Derived Growth Factor alpha
_xgenetics
650 0 4 _aReceptors, Cytokine
_xphysiology
650 0 4 _aRecombinant Fusion Proteins
_xadverse effects
650 0 4 _aSTAT Transcription Factors
_xphysiology
650 0 4 _aSequence Analysis, DNA
650 0 4 _aSignal Transduction
_xgenetics
650 0 4 _aSpleen
_xpathology
650 0 4 _aThrombocytosis
_xetiology
650 0 4 _aTranscription, Genetic
650 0 4 _amRNA Cleavage and Polyadenylation Factors
_xgenetics
700 1 _aLee, Benjamin H
700 1 _aMercher, Thomas
700 1 _aMcDowell, Elizabeth
700 1 _aEbert, Benjamin L
700 1 _aGozo, Maricel
700 1 _aCuker, Adam
700 1 _aWernig, Gerlinde
700 1 _aMoore, Sandra
700 1 _aGalinsky, Ilene
700 1 _aDeAngelo, Daniel J
700 1 _aClark, Jennifer J
700 1 _aLee, Stephanie J
700 1 _aGolub, Todd R
700 1 _aWadleigh, Martha
700 1 _aGilliland, D Gary
700 1 _aLevine, Ross L
773 0 _tPLoS medicine
_gvol. 3
_gno. 7
_gp. e270
856 4 0 _uhttps://doi.org/10.1371/journal.pmed.0030270
_zAvailable from publisher's website
999 _c16425666
_d16425666