000 02101 a2200517 4500
005 20250514233717.0
264 0 _c20050914
008 200509s 0 0 eng d
022 _a0008-5472
024 7 _a10.1158/0008-5472.CAN-05-0933
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aShimamura, Takeshi
245 0 0 _aEpidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins.
_h[electronic resource]
260 _bCancer research
_cJul 2005
300 _a6401-8 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
650 0 4 _aAnimals
650 0 4 _aAntibiotics, Antineoplastic
_xpharmacology
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aBenzoquinones
650 0 4 _aCarcinoma, Non-Small-Cell Lung
_xdrug therapy
650 0 4 _aCell Line, Tumor
650 0 4 _aCyclin D1
_xmetabolism
650 0 4 _aCysteine Proteinase Inhibitors
_xpharmacology
650 0 4 _aErbB Receptors
_xgenetics
650 0 4 _aGene Deletion
650 0 4 _aHSP90 Heat-Shock Proteins
_xantagonists & inhibitors
650 0 4 _aHumans
650 0 4 _aLactams, Macrocyclic
650 0 4 _aLung Neoplasms
_xdrug therapy
650 0 4 _aMice
650 0 4 _aMitogen-Activated Protein Kinase 1
_xantagonists & inhibitors
650 0 4 _aMitogen-Activated Protein Kinase 3
_xantagonists & inhibitors
650 0 4 _aNIH 3T3 Cells
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aProtein Serine-Threonine Kinases
_xantagonists & inhibitors
650 0 4 _aProtein Structure, Tertiary
650 0 4 _aProto-Oncogene Proteins
_xantagonists & inhibitors
650 0 4 _aProto-Oncogene Proteins c-akt
650 0 4 _aQuinones
_xpharmacology
700 1 _aLowell, April M
700 1 _aEngelman, Jeffrey A
700 1 _aShapiro, Geoffrey I
773 0 _tCancer research
_gvol. 65
_gno. 14
_gp. 6401-8
856 4 0 _uhttps://doi.org/10.1158/0008-5472.CAN-05-0933
_zAvailable from publisher's website
999 _c15679778
_d15679778