000 01986 a2200529 4500
005 20250514233202.0
264 0 _c20051025
008 200510s 0 0 eng d
022 _a0021-9258
024 7 _a10.1074/jbc.M503763200
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBasso, Andrea D
245 0 0 _aThe farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
_h[electronic resource]
260 _bThe Journal of biological chemistry
_cSep 2005
300 _a31101-8 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAlkyl and Aryl Transferases
_xantagonists & inhibitors
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xtherapeutic use
650 0 4 _aBridged-Ring Compounds
_xtherapeutic use
650 0 4 _aCaspases
_xmetabolism
650 0 4 _aCell Line, Tumor
650 0 4 _aFarnesyltranstransferase
650 0 4 _aHumans
650 0 4 _aMonomeric GTP-Binding Proteins
_xgenetics
650 0 4 _aNeoplasms
_xdrug therapy
650 0 4 _aNeuropeptides
_xgenetics
650 0 4 _aPhosphorylation
650 0 4 _aPiperidines
_xmetabolism
650 0 4 _aProtein Kinases
_xgenetics
650 0 4 _aProtein Prenylation
650 0 4 _aPyridines
_xmetabolism
650 0 4 _aRNA, Messenger
_xmetabolism
650 0 4 _aRas Homolog Enriched in Brain Protein
650 0 4 _aRecombinant Fusion Proteins
_xgenetics
650 0 4 _aSignal Transduction
_xphysiology
650 0 4 _aTOR Serine-Threonine Kinases
650 0 4 _aTamoxifen
_xtherapeutic use
650 0 4 _aTaxoids
_xtherapeutic use
700 1 _aMirza, Asra
700 1 _aLiu, Gongjie
700 1 _aLong, Brian J
700 1 _aBishop, W Robert
700 1 _aKirschmeier, Paul
773 0 _tThe Journal of biological chemistry
_gvol. 280
_gno. 35
_gp. 31101-8
856 4 0 _uhttps://doi.org/10.1074/jbc.M503763200
_zAvailable from publisher's website
999 _c15662777
_d15662777