000 02376 a2200745 4500
005 20250514223759.0
264 0 _c20050524
008 200505s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm0491086
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSchwarz, Jacob B
245 0 0 _aNovel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cApr 2005
300 _a3026-35 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAdministration, Oral
650 0 4 _aAmines
_xchemical synthesis
650 0 4 _aAmino Acid Transport System L
_xmetabolism
650 0 4 _aAmino Acids
_xchemistry
650 0 4 _aAnimals
650 0 4 _aAnticonvulsants
_xchemical synthesis
650 0 4 _aBiological Transport, Active
650 0 4 _aBlood-Brain Barrier
_xmetabolism
650 0 4 _aCHO Cells
650 0 4 _aCalcium Channels
_xdrug effects
650 0 4 _aCricetinae
650 0 4 _aCricetulus
650 0 4 _aCyclization
650 0 4 _aCyclohexanecarboxylic Acids
_xchemical synthesis
650 0 4 _aCyclopropanes
_xchemical synthesis
650 0 4 _aGabapentin
650 0 4 _aIn Vitro Techniques
650 0 4 _aInjections, Intraventricular
650 0 4 _aIon Channel Gating
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Inbred DBA
650 0 4 _aNitriles
_xchemistry
650 0 4 _aPregabalin
650 0 4 _aProtein Subunits
_xmetabolism
650 0 4 _aRats
650 0 4 _aRats, Sprague-Dawley
650 0 4 _aSwine
650 0 4 _agamma-Aminobutyric Acid
_xanalogs & derivatives
700 1 _aGibbons, Sian E
700 1 _aGraham, Shelley R
700 1 _aColbry, Norman L
700 1 _aGuzzo, Peter R
700 1 _aLe, Van-Duc
700 1 _aVartanian, Mark G
700 1 _aKinsora, Jack J
700 1 _aLotarski, Susan M
700 1 _aLi, Zheng
700 1 _aDickerson, Melvin R
700 1 _aSu, Ti-Zhi
700 1 _aWeber, Mark L
700 1 _aEl-Kattan, Ayman
700 1 _aThorpe, Andrew J
700 1 _aDonevan, Sean D
700 1 _aTaylor, Charles P
700 1 _aWustrow, David J
773 0 _tJournal of medicinal chemistry
_gvol. 48
_gno. 8
_gp. 3026-35
856 4 0 _uhttps://doi.org/10.1021/jm0491086
_zAvailable from publisher's website
999 _c15497492
_d15497492