000 02154 a2200601 4500
005 20250514220237.0
264 0 _c20050405
008 200504s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm0491849
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBaron, Bruce M
245 0 0 _aCoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cFeb 2005
300 _a995-1018 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAnticonvulsants
_xchemical synthesis
650 0 4 _aBinding Sites
650 0 4 _aCarboxylic Acids
_xchemical synthesis
650 0 4 _aCyclic GMP
_xbiosynthesis
650 0 4 _aGlycine
_xmetabolism
650 0 4 _aIn Vitro Techniques
650 0 4 _aIndoles
_xchemical synthesis
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Inbred DBA
650 0 4 _aModels, Molecular
650 0 4 _aNeuroprotective Agents
_xchemical synthesis
650 0 4 _aPhenylacetates
_xchemical synthesis
650 0 4 _aQuantitative Structure-Activity Relationship
650 0 4 _aRadioligand Assay
650 0 4 _aRats
650 0 4 _aRats, Sprague-Dawley
650 0 4 _aReceptors, N-Methyl-D-Aspartate
_xantagonists & inhibitors
650 0 4 _aSeizures
_xetiology
650 0 4 _aStereoisomerism
650 0 4 _aStroke
_xdrug therapy
700 1 _aCregge, Robert J
700 1 _aFarr, Robert A
700 1 _aFriedrich, Dirk
700 1 _aGross, Raymond S
700 1 _aHarrison, Boyd L
700 1 _aJanowick, David A
700 1 _aMatthews, Donald
700 1 _aMcCloskey, Timothy C
700 1 _aMeikrantz, Scott
700 1 _aNyce, Philip L
700 1 _aVaz, Roy
700 1 _aMetz, William A
773 0 _tJournal of medicinal chemistry
_gvol. 48
_gno. 4
_gp. 995-1018
856 4 0 _uhttps://doi.org/10.1021/jm0491849
_zAvailable from publisher's website
999 _c15391119
_d15391119