000 01949 a2200481 4500
005 20250514215808.0
264 0 _c20050705
008 200507s 0 0 eng d
022 _a0022-3565
024 7 _a10.1124/jpet.104.079285
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSivarao, Digavalli V
245 0 0 _aEffect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.
_h[electronic resource]
260 _bThe Journal of pharmacology and experimental therapeutics
_cMay 2005
300 _a840-7 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article
650 0 4 _aAnimals
650 0 4 _aBlood Pressure
_xdrug effects
650 0 4 _aColon
_xdrug effects
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aFemale
650 0 4 _aGastrointestinal Motility
_xdrug effects
650 0 4 _aIon Channel Gating
_xdrug effects
650 0 4 _aLarge-Conductance Calcium-Activated Potassium Channels
650 0 4 _aPain Measurement
_xdrug effects
650 0 4 _aPotassium Channels, Calcium-Activated
_xagonists
650 0 4 _aQuinolines
_xadministration & dosage
650 0 4 _aQuinolones
_xadministration & dosage
650 0 4 _aRats
650 0 4 _aRats, Wistar
650 0 4 _aStress, Physiological
_xdrug therapy
650 0 4 _aViscera
_xdrug effects
700 1 _aNewberry, Kimberly
700 1 _aLangdon, Shaun
700 1 _aLee, Alicia V
700 1 _aHewawasam, Piyasena
700 1 _aPlym, Mary Jane
700 1 _aSignor, Laura
700 1 _aMyers, Robert
700 1 _aLodge, Nicholas J
773 0 _tThe Journal of pharmacology and experimental therapeutics
_gvol. 313
_gno. 2
_gp. 840-7
856 4 0 _uhttps://doi.org/10.1124/jpet.104.079285
_zAvailable from publisher's website
999 _c15378178
_d15378178