000			01596 a2200421 4500
005			20250511184438.0
264		0	_c19921228
008			199212s 0 0 eng d
022			_a0022-2623
024	7		_a10.1021/jm00101a023 _2doi
040			_aNLM _beng _cNLM
100	1		_aTaylor, E C
245	0	0	_aA dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. _h[electronic resource]
260			_bJournal of medicinal chemistry _cNov 1992
300			_a4450-4 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aGlutamates _xchemical synthesis
650	0	4	_aGuanine _xanalogs & derivatives
650	0	4	_aHumans
650	0	4	_aLeukemia L1210 _xdrug therapy
650	0	4	_aLeukemia, Lymphoid _xdrug therapy
650	0	4	_aMice
650	0	4	_aPemetrexed
650	0	4	_aStructure-Activity Relationship
650	0	4	_aThymidylate Synthase _xantagonists & inhibitors
650	0	4	_aTumor Cells, Cultured
700	1		_aKuhnt, D
700	1		_aShih, C
700	1		_aRinzel, S M
700	1		_aGrindey, G B
700	1		_aBarredo, J
700	1		_aJannatipour, M
700	1		_aMoran, R G
773	0		_tJournal of medicinal chemistry _gvol. 35 _gno. 23 _gp. 4450-4
856	4	0	_uhttps://doi.org/10.1021/jm00101a023 _zAvailable from publisher's website
999			_c1454234 _d1454234