000 02480 a2200673 4500
005 20250514165050.0
264 0 _c20040913
008 200409s 0 0 eng d
022 _a0090-9556
024 7 _a10.1124/dmd.32.1.149
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKoyano, Satoru
245 0 0 _aFunctional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
_h[electronic resource]
260 _bDrug metabolism and disposition: the biological fate of chemicals
_cJan 2004
300 _a149-54 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAmino Acid Sequence
650 0 4 _aAnimals
650 0 4 _aBiotransformation
_xdrug effects
650 0 4 _aBlotting, Western
650 0 4 _aCOS Cells
650 0 4 _aCell Line, Tumor
650 0 4 _aChlorocebus aethiops
650 0 4 _aClotrimazole
_xpharmacology
650 0 4 _aCytochrome P-450 CYP3A
650 0 4 _aCytochrome P-450 Enzyme System
_xgenetics
650 0 4 _aDNA
_xgenetics
650 0 4 _aElectrophoretic Mobility Shift Assay
650 0 4 _aEnhancer Elements, Genetic
_xgenetics
650 0 4 _aExons
_xgenetics
650 0 4 _aGenes, Reporter
_xgenetics
650 0 4 _aHumans
650 0 4 _aImmunohistochemistry
650 0 4 _aLuciferases
_xgenetics
650 0 4 _aMolecular Sequence Data
650 0 4 _aPaclitaxel
_xpharmacology
650 0 4 _aPlasmids
_xgenetics
650 0 4 _aPregnane X Receptor
650 0 4 _aPromoter Regions, Genetic
_xgenetics
650 0 4 _aReceptors, Cytoplasmic and Nuclear
_xgenetics
650 0 4 _aReceptors, Steroid
_xgenetics
650 0 4 _aRifampin
_xpharmacology
650 0 4 _aTranscriptional Activation
_xgenetics
700 1 _aKurose, Kouichi
700 1 _aSaito, Yoshiro
700 1 _aOzawa, Shogo
700 1 _aHasegawa, Ryuichi
700 1 _aKomamura, Kazuo
700 1 _aUeno, Kazuyuki
700 1 _aKamakura, Shiro
700 1 _aKitakaze, Masafumi
700 1 _aNakajima, Toshiharu
700 1 _aMatsumoto, Kenji
700 1 _aAkasawa, Akira
700 1 _aSaito, Hirohisa
700 1 _aSawada, Jun-Ichi
773 0 _tDrug metabolism and disposition: the biological fate of chemicals
_gvol. 32
_gno. 1
_gp. 149-54
856 4 0 _uhttps://doi.org/10.1124/dmd.32.1.149
_zAvailable from publisher's website
999 _c14438663
_d14438663