| 000 | 01619 a2200457 4500 | ||
|---|---|---|---|
| 005 | 20250514075707.0 | ||
| 264 | 0 | _c20031007 | |
| 008 | 200310s 0 0 eng d | ||
| 022 | _a0006-2960 | ||
| 024 | 7 |
_a10.1021/bi0349322 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aQuinsey, Noelene S | |
| 245 | 0 | 0 |
_aIntroduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. _h[electronic resource] |
| 260 |
_bBiochemistry _cSep 2003 |
||
| 300 |
_a10169-73 p. _bdigital |
||
| 500 | _aPublication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 | _aAmino Acid Substitution |
| 650 | 0 | 4 |
_aAntithrombins _xchemistry |
| 650 | 0 | 4 | _aDrug Stability |
| 650 | 0 | 4 |
_aHeparin _xanalogs & derivatives |
| 650 | 0 | 4 | _aHot Temperature |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aKinetics |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMutagenesis, Site-Directed |
| 650 | 0 | 4 | _aOsmolar Concentration |
| 650 | 0 | 4 | _aProtein Denaturation |
| 650 | 0 | 4 | _aProtein Structure, Secondary |
| 650 | 0 | 4 |
_aRecombinant Proteins _xchemistry |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aalpha 1-Antitrypsin _xchemistry |
| 700 | 1 | _aFitton, Hazel L | |
| 700 | 1 | _aCoughlin, Paul | |
| 700 | 1 | _aWhisstock, James C | |
| 700 | 1 | _aDafforn, Timothy R | |
| 700 | 1 | _aCarrell, Robin W | |
| 700 | 1 | _aBottomley, Stephen P | |
| 700 | 1 | _aPike, Robert N | |
| 773 | 0 |
_tBiochemistry _gvol. 42 _gno. 34 _gp. 10169-73 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/bi0349322 _zAvailable from publisher's website |
| 999 |
_c12709299 _d12709299 |
||