000 02135 a2200625 4500
005 20250514072314.0
264 0 _c20030807
008 200308s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm020587n
_2doi
040 _aNLM
_beng
_cNLM
100 1 _adeSolms, S Jane
245 0 0 _aDual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cJul 2003
300 _a2973-84 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAlkyl and Aryl Transferases
_xantagonists & inhibitors
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aCarrier Proteins
_xmetabolism
650 0 4 _aCrystallography, X-Ray
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aHSP40 Heat-Shock Proteins
650 0 4 _aHeat-Shock Proteins
_xmetabolism
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aMice, Nude
650 0 4 _aModels, Molecular
650 0 4 _aNeoplasm Transplantation
650 0 4 _aNeoplasms, Experimental
_xdrug therapy
650 0 4 _aProtein Prenylation
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTransplantation, Heterologous
650 0 4 _aTumor Cells, Cultured
650 0 4 _arap1 GTP-Binding Proteins
_xmetabolism
650 0 4 _aras Proteins
_xmetabolism
700 1 _aCiccarone, Terrence M
700 1 _aMacTough, Suzanne C
700 1 _aShaw, Anthony W
700 1 _aBuser, Carolyn A
700 1 _aEllis-Hutchings, Michelle
700 1 _aFernandes, Christine
700 1 _aHamilton, Kelly A
700 1 _aHuber, Hans E
700 1 _aKohl, Nancy E
700 1 _aLobell, Robert B
700 1 _aRobinson, Ronald G
700 1 _aTsou, Nancy N
700 1 _aWalsh, Eileen S
700 1 _aGraham, Samuel L
700 1 _aBeese, Lorena S
700 1 _aTaylor, Jeffrey S
773 0 _tJournal of medicinal chemistry
_gvol. 46
_gno. 14
_gp. 2973-84
856 4 0 _uhttps://doi.org/10.1021/jm020587n
_zAvailable from publisher's website
999 _c12608988
_d12608988