000			02028 a2200517 4500
005			20250514062304.0
264		0	_c20030410
008			200304s 0 0 eng d
022			_a0732-183X
024	7		_a10.1200/JCO.2003.08.049 _2doi
040			_aNLM _beng _cNLM
100	1		_aChester, John D
245	0	0	_aPhase I and pharmacokinetic study of intravenous irinotecan plus oral ciclosporin in patients with fuorouracil-refractory metastatic colon cancer. _h[electronic resource]
260			_bJournal of clinical oncology : official journal of the American Society of Clinical Oncology _cMar 2003
300			_a1125-32 p. _bdigital
500			_aPublication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdministration, Oral
650	0	4	_aAdult
650	0	4	_aAged
650	0	4	_aAntimetabolites, Antineoplastic _xpharmacology
650	0	4	_aAntineoplastic Agents, Phytogenic _xadministration & dosage
650	0	4	_aAntineoplastic Combined Chemotherapy Protocols _xadministration & dosage
650	0	4	_aCamptothecin _xadministration & dosage
650	0	4	_aColonic Neoplasms _xblood
650	0	4	_aCyclosporine _xadministration & dosage
650	0	4	_aDrug Resistance, Neoplasm
650	0	4	_aFemale
650	0	4	_aFluorouracil _xpharmacology
650	0	4	_aHumans
650	0	4	_aInfusions, Intravenous
650	0	4	_aIrinotecan
650	0	4	_aMale
650	0	4	_aMiddle Aged
650	0	4	_aNeoplasm Staging
650	0	4	_aTreatment Outcome
700	1		_aJoel, Simon P
700	1		_aCheeseman, Susan L
700	1		_aHall, Geoffrey D
700	1		_aBraun, Michael S
700	1		_aPerry, Jackie
700	1		_aDavis, Theresa
700	1		_aButton, Christopher J
700	1		_aSeymour, Matthew T
773	0		_tJournal of clinical oncology : official journal of the American Society of Clinical Oncology _gvol. 21 _gno. 6 _gp. 1125-32
856	4	0	_uhttps://doi.org/10.1200/JCO.2003.08.049 _zAvailable from publisher's website
999			_c12432025 _d12432025