000 01673 a2200469 4500
005 20250514054105.0
264 0 _c20030204
008 200302s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm020367+
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHay, Michael P
245 0 0 _aStructure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cJan 2003
300 _a169-82 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aCell Division
_xdrug effects
650 0 4 _aCell Hypoxia
_xdrug effects
650 0 4 _aCyclic N-Oxides
_xchemical synthesis
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aHumans
650 0 4 _aInhibitory Concentration 50
650 0 4 _aMice
650 0 4 _aOxidation-Reduction
650 0 4 _aSolubility
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTirapazamine
650 0 4 _aTriazines
_xchemical synthesis
650 0 4 _aTumor Cells, Cultured
700 1 _aGamage, Swarna A
700 1 _aKovacs, Mary S
700 1 _aPruijn, Frederik B
700 1 _aAnderson, Robert F
700 1 _aPatterson, Adam V
700 1 _aWilson, William R
700 1 _aBrown, J Martin
700 1 _aDenny, William A
773 0 _tJournal of medicinal chemistry
_gvol. 46
_gno. 1
_gp. 169-82
856 4 0 _uhttps://doi.org/10.1021/jm020367+
_zAvailable from publisher's website
999 _c12305901
_d12305901