000			02278 a2200637 4500
005			20250514054104.0
264		0	_c20030204
008			200302s 0 0 eng d
022			_a0022-2623
024	7		_a10.1021/jm020241c _2doi
040			_aNLM _beng _cNLM
100	1		_aWissner, Allan
245	0	0	_aSynthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2). _h[electronic resource]
260			_bJournal of medicinal chemistry _cJan 2003
300			_a49-63 p. _bdigital
500			_aPublication Type: Journal Article
650	0	4	_aAdministration, Oral
650	0	4	_aAminoquinolines
650	0	4	_aAniline Compounds
650	0	4	_aAnimals
650	0	4	_aAntineoplastic Agents _xchemical synthesis
650	0	4	_aCell Division _xdrug effects
650	0	4	_aEnzyme Inhibitors _xchemical synthesis
650	0	4	_aErbB Receptors _xantagonists & inhibitors
650	0	4	_aGlutathione _xantagonists & inhibitors
650	0	4	_aHumans
650	0	4	_aMice
650	0	4	_aModels, Molecular
650	0	4	_aOrganic Chemicals
650	0	4	_aPhosphorylation
650	0	4	_aReceptor, ErbB-2 _xantagonists & inhibitors
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSubstrate Specificity
650	0	4	_aTumor Cells, Cultured
650	0	4	_aXenograft Model Antitumor Assays
700	1		_aOverbeek, Elsebe
700	1		_aReich, Marvin F
700	1		_aFloyd, M Brawner
700	1		_aJohnson, Bernard D
700	1		_aMamuya, Nellie
700	1		_aRosfjord, Edward C
700	1		_aDiscafani, Carolyn
700	1		_aDavis, Rachel
700	1		_aShi, Xiaoqing
700	1		_aRabindran, Sridhar K
700	1		_aGruber, Brian C
700	1		_aYe, Fei
700	1		_aHallett, William A
700	1		_aNilakantan, Ramaswamy
700	1		_aShen, Ru
700	1		_aWang, Yu-Fen
700	1		_aGreenberger, Lee M
700	1		_aTsou, Hwei-Ru
773	0		_tJournal of medicinal chemistry _gvol. 46 _gno. 1 _gp. 49-63
856	4	0	_uhttps://doi.org/10.1021/jm020241c _zAvailable from publisher's website
999			_c12305888 _d12305888