000 01715 a2200469 4500
005 20250514051751.0
264 0 _c20021220
008 200212s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm0209331
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMacKenzie, A Roderick
245 0 0 _aStructure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)- 5-[2-[(3-substituted)-1-azetidinyl]ethyl]-2-piperidones. 1. Selective antagonists of the neurokinin-2 receptor.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cNov 2002
300 _a5365-77 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAzetidines
_xchemical synthesis
650 0 4 _aCHO Cells
650 0 4 _aCricetinae
650 0 4 _aDrug Stability
650 0 4 _aHumans
650 0 4 _aIn Vitro Techniques
650 0 4 _aMicrosomes, Liver
_xmetabolism
650 0 4 _aMuscle Contraction
_xdrug effects
650 0 4 _aMuscle, Smooth
_xdrug effects
650 0 4 _aPiperazines
_xchemical synthesis
650 0 4 _aPiperidones
_xchemical synthesis
650 0 4 _aPulmonary Artery
_xdrug effects
650 0 4 _aRabbits
650 0 4 _aRadioligand Assay
650 0 4 _aReceptors, Neurokinin-2
_xantagonists & inhibitors
650 0 4 _aReceptors, Neurokinin-3
_xmetabolism
650 0 4 _aStereoisomerism
650 0 4 _aStructure-Activity Relationship
700 1 _aMarchington, Allan P
700 1 _aMiddleton, Donald S
700 1 _aNewman, Sandra D
700 1 _aJones, Barry C
773 0 _tJournal of medicinal chemistry
_gvol. 45
_gno. 24
_gp. 5365-77
856 4 0 _uhttps://doi.org/10.1021/jm0209331
_zAvailable from publisher's website
999 _c12238154
_d12238154