000 01656 a2200457 4500
005 20250514020926.0
264 0 _c20020122
008 200201s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm0102203
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBorthwick, Alan D
245 0 0 _aDesign and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cJan 2002
300 _a1-18 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAntiviral Agents
_xchemical synthesis
650 0 4 _aBinding Sites
650 0 4 _aCrystallography, X-Ray
650 0 4 _aCytomegalovirus
_xchemistry
650 0 4 _aLactams
_xchemical synthesis
650 0 4 _aMass Spectrometry
650 0 4 _aModels, Molecular
650 0 4 _aProtease Inhibitors
_xchemical synthesis
650 0 4 _aPyrroles
_xchemical synthesis
650 0 4 _aSerine Endopeptidases
_xchemistry
650 0 4 _aStereoisomerism
650 0 4 _aStructure-Activity Relationship
700 1 _aCrame, Andrew J
700 1 _aErtl, Peter F
700 1 _aExall, Anne M
700 1 _aHaley, Terry M
700 1 _aHart, Graham J
700 1 _aMason, Andrew M
700 1 _aPennell, Andrew M K
700 1 _aSingh, Onkar M P
700 1 _aWeingarten, Gordon G
700 1 _aWoolven, James M
773 0 _tJournal of medicinal chemistry
_gvol. 45
_gno. 1
_gp. 1-18
856 4 0 _uhttps://doi.org/10.1021/jm0102203
_zAvailable from publisher's website
999 _c11666992
_d11666992