| 000 | 01867 a2200529 4500 | ||
|---|---|---|---|
| 005 | 20250514004944.0 | ||
| 264 | 0 | _c20010906 | |
| 008 | 200109s 0 0 eng d | ||
| 022 | _a0022-2623 | ||
| 024 | 7 |
_a10.1021/jm015521r _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aThomas, J B | |
| 245 | 0 | 0 |
_aIdentification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cAug 2001 |
||
| 300 |
_a2687-90 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aBinding, Competitive |
| 650 | 0 | 4 |
_aBrain _xmetabolism |
| 650 | 0 | 4 | _aCloning, Molecular |
| 650 | 0 | 4 | _aGuinea Pigs |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aIn Vitro Techniques |
| 650 | 0 | 4 |
_aIsoquinolines _xchemical synthesis |
| 650 | 0 | 4 |
_aNarcotic Antagonists _xchemical synthesis |
| 650 | 0 | 4 |
_aPiperidines _xchemical synthesis |
| 650 | 0 | 4 | _aRadioligand Assay |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 |
_aReceptors, Opioid, delta _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aReceptors, Opioid, kappa _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aReceptors, Opioid, mu _xantagonists & inhibitors |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 | _aTetrahydroisoquinolines |
| 700 | 1 | _aAtkinson, R N | |
| 700 | 1 | _aRothman, R B | |
| 700 | 1 | _aFix, S E | |
| 700 | 1 | _aMascarella, S W | |
| 700 | 1 | _aVinson, N A | |
| 700 | 1 | _aXu, H | |
| 700 | 1 | _aDersch, C M | |
| 700 | 1 | _aLu, Y | |
| 700 | 1 | _aCantrell, B E | |
| 700 | 1 | _aZimmerman, D M | |
| 700 | 1 | _aCarroll, F I | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 44 _gno. 17 _gp. 2687-90 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm015521r _zAvailable from publisher's website |
| 999 |
_c11420961 _d11420961 |
||