000 01870 a2200565 4500
005 20250513201532.0
264 0 _c20000228
008 200002s 0 0 eng d
022 _a0960-894X
024 7 _a10.1016/s0960-894x(99)00573-9
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPascal, Y
245 0 0 _aSynthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_cJan 2000
300 _a35-8 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _a3',5'-Cyclic-AMP Phosphodiesterases
_xantagonists & inhibitors
650 0 4 _aAnimals
650 0 4 _aBenzodiazepines
_xchemical synthesis
650 0 4 _aBinding Sites
650 0 4 _aCyclic Nucleotide Phosphodiesterases, Type 4
650 0 4 _aDogs
650 0 4 _aGuinea Pigs
650 0 4 _aHumans
650 0 4 _aIndoles
_xchemical synthesis
650 0 4 _aInhibitory Concentration 50
650 0 4 _aPhosphodiesterase Inhibitors
_xchemical synthesis
650 0 4 _aRats
650 0 4 _aRats, Inbred BN
650 0 4 _aRats, Wistar
650 0 4 _aRolipram
_xmetabolism
650 0 4 _aStereoisomerism
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSubstrate Specificity
650 0 4 _aU937 Cells
700 1 _aAndrianjara, C R
700 1 _aAuclair, E
700 1 _aAvenel, N
700 1 _aBertin, B
700 1 _aCalvet, A
700 1 _aFéru, F
700 1 _aLardon, S
700 1 _aMoodley, I
700 1 _aOuagued, M
700 1 _aPayne, A
700 1 _aPruniaux, M P
700 1 _aSzilagyi, C
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 10
_gno. 1
_gp. 35-8
856 4 0 _uhttps://doi.org/10.1016/s0960-894x(99)00573-9
_zAvailable from publisher's website
999 _c10591570
_d10591570