| 000 | 01518 a2200385 4500 | ||
|---|---|---|---|
| 005 | 20250513183601.0 | ||
| 264 | 0 | _c19990716 | |
| 008 | 199907s 0 0 eng d | ||
| 022 | _a0090-9556 | ||
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aDehal, S S | |
| 245 | 0 | 0 |
_aCytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. _h[electronic resource] |
| 260 |
_bDrug metabolism and disposition: the biological fate of chemicals _cJun 1999 |
||
| 300 |
_a681-8 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. | ||
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aBiotransformation |
| 650 | 0 | 4 |
_aCatechols _xmetabolism |
| 650 | 0 | 4 |
_aCytochrome P-450 CYP2D6 _xbiosynthesis |
| 650 | 0 | 4 | _aCytochrome P-450 CYP3A |
| 650 | 0 | 4 |
_aCytochrome P-450 Enzyme System _xbiosynthesis |
| 650 | 0 | 4 |
_aEstrogen Antagonists _xpharmacokinetics |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aHydroxylation |
| 650 | 0 | 4 | _aIn Vitro Techniques |
| 650 | 0 | 4 |
_aLiver _xdrug effects |
| 650 | 0 | 4 |
_aMixed Function Oxygenases _xbiosynthesis |
| 650 | 0 | 4 |
_aPentobarbital _xpharmacology |
| 650 | 0 | 4 | _aProtein Binding |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 | _aRats, Sprague-Dawley |
| 650 | 0 | 4 |
_aTamoxifen _xanalogs & derivatives |
| 700 | 1 | _aKupfer, D | |
| 773 | 0 |
_tDrug metabolism and disposition: the biological fate of chemicals _gvol. 27 _gno. 6 _gp. 681-8 |
|
| 999 |
_c10307465 _d10307465 |
||