000 01897 a2200529 4500
005 20250513170030.0
264 0 _c19990316
008 199903s 0 0 eng d
022 _a0022-2623
024 7 _a10.1021/jm980567e
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGroneberg, R D
245 0 0 _aDual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cFeb 1999
300 _a541-4 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _a3',5'-Cyclic-AMP Phosphodiesterases
_xantagonists & inhibitors
650 0 4 _aAnimals
650 0 4 _aCyclic Nucleotide Phosphodiesterases, Type 4
650 0 4 _aFibroblasts
_xenzymology
650 0 4 _aGelatinases
_xantagonists & inhibitors
650 0 4 _aGuinea Pigs
650 0 4 _aHydroxamic Acids
_xchemical synthesis
650 0 4 _aMacrophages
_xenzymology
650 0 4 _aMatrix Metalloproteinase 1
650 0 4 _aMatrix Metalloproteinase 2
650 0 4 _aMatrix Metalloproteinase Inhibitors
650 0 4 _aMetalloendopeptidases
_xantagonists & inhibitors
650 0 4 _aPhosphodiesterase Inhibitors
_xchemical synthesis
650 0 4 _aProtease Inhibitors
_xchemical synthesis
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSulfones
_xchemical synthesis
700 1 _aBurns, C J
700 1 _aMorrissette, M M
700 1 _aUllrich, J W
700 1 _aMorris, R L
700 1 _aDarnbrough, S
700 1 _aDjuric, S W
700 1 _aCondon, S M
700 1 _aMcGeehan, G M
700 1 _aLabaudiniere, R
700 1 _aNeuenschwander, K
700 1 _aScotese, A C
700 1 _aKline, J A
773 0 _tJournal of medicinal chemistry
_gvol. 42
_gno. 4
_gp. 541-4
856 4 0 _uhttps://doi.org/10.1021/jm980567e
_zAvailable from publisher's website
999 _c10013471
_d10013471