Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. [electronic resource]
Producer: 20190225Description: 655-666 p. digitalISSN:- 1096-0929
- Cell Survival -- drug effects
- Cells, Cultured
- Chemical and Drug Induced Liver Injury -- pathology
- Coculture Techniques
- Cryopreservation
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Hepatocytes -- drug effects
- Humans
- Male
- Middle Aged
- Models, Biological
- Pharmaceutical Preparations -- administration & dosage
- Predictive Value of Tests
- Primary Cell Culture
- Spheroids, Cellular -- drug effects
- Time Factors
- Toxicity Tests -- methods
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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