Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. [electronic resource]
Producer: 20120316Description: e243 p. digitalISSN:- 2041-4889
- Adaptation, Biological -- drug effects
- Antineoplastic Agents -- pharmacology
- Caspase 3 -- metabolism
- Caspase 7 -- metabolism
- Drug Resistance, Neoplasm -- genetics
- Humans
- Imidazoles -- pharmacology
- Mutation
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- RNA Interference
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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