Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. [electronic resource]
Producer: 20120604Description: 757-68 p. digitalISSN:- 1476-5551
- Amino Acid Substitution
- Antineoplastic Agents -- metabolism
- Boronic Acids -- metabolism
- Bortezomib
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Humans
- Multiple Myeloma -- drug therapy
- Mutation
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Proteasome Endopeptidase Complex -- genetics
- Proteasome Inhibitors
- Pyrazines -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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