Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. [electronic resource]
Producer: 20040708Description: 4188-94 p. digitalISSN:- 0006-4971
- Animals
- Atorvastatin
- C-Reactive Protein -- genetics
- CCAAT-Enhancer-Binding Proteins -- metabolism
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cholesterol -- blood
- Down-Regulation -- drug effects
- Gene Expression -- drug effects
- Hepatocytes -- cytology
- Heptanoic Acids -- pharmacology
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- I-kappa B Proteins -- metabolism
- In Vitro Techniques
- Interleukin-1 -- pharmacology
- Male
- Mice
- Mice, Transgenic
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- NF-kappa B p50 Subunit
- Pyrroles -- pharmacology
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Simvastatin -- pharmacology
- Transcription Factors -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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