Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. [electronic resource]
Producer: 20030826Description: 3463-75 p. digitalISSN:- 0022-2623
- Analgesics -- chemical synthesis
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Arthritis, Experimental -- drug therapy
- Binding Sites
- Cell Line
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- chemical synthesis
- Dinoprostone -- biosynthesis
- Humans
- Imidazoles -- chemical synthesis
- Inflammation -- metabolism
- Isoenzymes -- antagonists & inhibitors
- Male
- Membrane Proteins
- Models, Molecular
- Pain Measurement
- Peptic Ulcer -- chemically induced
- Prostaglandin-Endoperoxide Synthases
- Rats
- Rats, Inbred Lew
- Rats, Sprague-Dawley
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
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Publication Type: Journal Article
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