Design and synthesis of 4-(2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridine-2-yl)pyrimidin-2-amine as a highly potent and selective cyclin-dependent kinases 4 and 6 inhibitors and the discovery of structure-activity relationships. [electronic resource]
Producer: 20181002Description: 974-978 p. digitalISSN:- 1464-3405
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Dose-Response Relationship, Drug
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Imidazoles -- chemical synthesis
- Molecular Structure
- Piperazines -- chemical synthesis
- Protein Kinase Inhibitors -- chemical synthesis
- Pyridines -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Pyrroles -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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