'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. [electronic resource]
Producer: 20070712Description: 3972-9 p. digitalISSN:- 0950-9232
- 3' Untranslated Regions -- genetics
- Antineoplastic Agents -- pharmacology
- Base Sequence
- Benzenesulfonates -- pharmacology
- Biphenyl Compounds -- pharmacology
- Blotting, Western
- Carcinoma, Small Cell -- drug therapy
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA-Binding Proteins -- genetics
- Drug Resistance, Neoplasm -- drug effects
- Humans
- Lung Neoplasms -- drug therapy
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- genetics
- Niacinamide -- analogs & derivatives
- Nitrophenols -- pharmacology
- Phenylurea Compounds
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Purines -- pharmacology
- Pyridines -- pharmacology
- RNA Interference
- RNA, Small Interfering -- genetics
- Receptor, Fibroblast Growth Factor, Type 2
- Roscovitine
- Sorafenib
- Sulfonamides -- pharmacology
- Transmembrane Activator and CAML Interactor Protein -- genetics
- Zinc Fingers -- genetics
- bcl-X Protein -- antagonists & inhibitors
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Publication Type: Journal Article
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