Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction. [electronic resource]
Producer: 20120321Description: 185-91 p. digitalISSN:- 1573-4978
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Hypoxia -- physiology
- Cell Line, Tumor
- Chromatin Immunoprecipitation
- DNA Primers -- genetics
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Inhibitor of Apoptosis Proteins -- metabolism
- RNA Interference
- RNA, Small Interfering -- genetics
- Real-Time Polymerase Chain Reaction
- Sirolimus -- pharmacology
- Survivin
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article
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