Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan. [electronic resource]
Producer: 20180803Description: 3344-3349 p. digitalISSN:- 1791-3004
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Camptothecin -- analogs & derivatives
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colonic Neoplasms -- drug therapy
- DNA Damage -- drug effects
- Enzyme Inhibitors -- pharmacology
- Humans
- Irinotecan
- Mutation
- Nuclear Proteins -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Pyrimidinones
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article
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