Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma. [electronic resource]
Producer: 20200415Description: 140 p. digitalISSN:- 1476-4598
- Animals
- Apoptosis -- drug effects
- Biomarkers, Tumor
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cyclin-Dependent Kinase 9 -- genetics
- Cyclin-Dependent Kinases -- genetics
- Disease Models, Animal
- Gene Expression Regulation, Neoplastic
- Humans
- Kruppel-Like Factor 4
- Liver Neoplasms -- drug therapy
- Male
- Melanoma -- drug therapy
- Mice
- Oncogene Addiction -- genetics
- Oxazoles -- pharmacology
- Signal Transduction
- Thiazoles -- pharmacology
- Transcription Factors -- metabolism
- Uveal Neoplasms -- drug therapy
- Xenograft Model Antitumor Assays
- Cyclin-Dependent Kinase-Activating Kinase
- Uveal Melanoma
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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