Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C. [electronic resource]
Producer: 20000106Description: 641-50 p. digitalISSN:- 0960-314X
- Adenosine Triphosphate -- metabolism
- Alleles
- Animals
- COS Cells
- Cysteine Endopeptidases -- metabolism
- DNA, Complementary -- genetics
- Humans
- In Vitro Techniques
- Kinetics
- Methyltransferases -- deficiency
- Multienzyme Complexes -- metabolism
- Mutation
- Proteasome Endopeptidase Complex
- Rabbits
- Recombinant Proteins -- genetics
- Reticulocytes -- metabolism
- S-Adenosylmethionine -- pharmacology
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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