Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. [electronic resource]
Producer: 20101104Description: 13707-17 p. digitalISSN:- 1529-2401
- Age Factors
- Analysis of Variance
- Animals
- Apolipoprotein E4 -- genetics
- Cells, Cultured
- Dentate Gyrus -- drug effects
- Electrophysiology
- Female
- Immunohistochemistry
- Interneurons -- drug effects
- Maze Learning -- drug effects
- Memory Disorders -- metabolism
- Mice
- Mice, Transgenic
- Nerve Degeneration -- genetics
- Pentobarbital -- administration & dosage
- Presynaptic Terminals -- physiology
- Statistics, Nonparametric
- gamma-Aminobutyric Acid -- metabolism
- tau Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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