Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. [electronic resource]
Producer: 20171005Description: 19354-19364 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Biomarkers, Tumor -- genetics
- Carcinoma, Hepatocellular -- drug therapy
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm
- Endoplasmic Reticulum Chaperone BiP
- ErbB Receptors -- genetics
- Gene Expression Regulation, Neoplastic -- drug effects
- Heat-Shock Proteins -- genetics
- Humans
- Liver Neoplasms -- drug therapy
- Mice
- Mice, Nude
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins pp60(c-src) -- genetics
- STAT3 Transcription Factor -- genetics
- Signal Transduction -- drug effects
- Sorafenib
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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