Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. [electronic resource]
Producer: 20191029Description: 1494-1508 p. digitalISSN:- 1365-2222
- Allergens -- immunology
- Animals
- Asthma -- drug therapy
- Biomarkers
- Curcumin -- analogs & derivatives
- Cytokines -- metabolism
- Disease Models, Animal
- Female
- Inflammation Mediators -- metabolism
- Jagged-1 Protein -- metabolism
- Jagged-2 Protein -- metabolism
- Janus Kinase 1 -- metabolism
- Leukocytes -- immunology
- Mice
- Oxidative Stress
- Receptor, Notch1 -- metabolism
- Receptor, Notch2 -- metabolism
- Receptors, Cell Surface -- metabolism
- STAT6 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Th2 Cells -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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